antiulcerogenic activity of stem extract and fractions of homalium letestui

background & aim: homalium letestui pellegr (flacourtiaceae) used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  experimental: the effects of ethanol stem extract of h. letestui (200 – 600 mg/kg) and fractions (aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models.  results & discussion: the extract (200 – 600 mg/kg) inhibited ethanol, indomethacin, reserpine and histamine –induced ulcer models in a dose dependent fashion. the various degrees of inhibitions were statistically significant (p